High Production Volume

In 1998, the global chemical industry, through the ICCA and in cooperation with the Organisation for Economic Cooperation and Development (OECD), launched the High Production Volume (HPV) Chemicals Initiative. Under this program, screening-level hazard data is collected and submitted to the OECD member countries for hazard assessment. 

The information presented for assessment is the internationally agreed-upon Screening Initial Data Set (SIDS), which consists of six categories: 

  • Acute toxicity
  • Repeat dose toxicity
  • Reproductive/developmental toxicity
  • Genetic toxicity
  • Ecotoxicity
  • Environmental fate

The data set provides a sound basis for the initial hazard assessment of the chemical, which is prepared by the industry and country sponsor, and is presented for assessment at the OECD SIDS Initial Assessment Meeting (SIAM). 

The prime responsibility under this initiative rests with all chemical companies producing HPV chemicals. They are responsible for collecting the hazard information and, where necessary, to conduct tests to supplement the existing hazard information. Companies often join together in international consortia, often as members of panels or product sector groups, to undertake this work.

Companies continue to offer high-level support and encouragement, both to ICCA member associations and individual companies, in order to ensure effective and efficient implementation of the HPV Chemicals initiative and to meet its deadline of end 2010.

ICCA member associations continue to promote work on the initiative, and to provide information to their membership on how to participate and on its progress. They are committed to establish and maintain an open and transparent communication process with all involved stakeholders, governments, and the general public.


The latest publication

Welcome note from ICCA President Mark Rohr (23 January 2015) 

Welcome note from ICCA President Mark Rohr

PDF [77KB]


More information and resources


ICCA HPV Working List (01 July 2000) 

PDF [124KB]


Joint Letter of Concern Regarding WHO-UNEP State of the Science on Endocrine Disrupting Chemicals - 2012 (31 March 2014) 

ICCA and CropLife International send joint letter to WHO and UNEP.

PDF [883KB]